Maybe a different religion, or especially political beliefs seems to be a big deal-breaker. Do you still find it worthwhile to keep them in your life?
I do. I have e.g. Christian Conservative friends, and Atheist Liberal ones, etc. I enjoy each one for what they are. I mean, nobody is perfect! (like me 😁)
I’m a boring middle aged man, so I don’t really have friends besides my D&D group, and it was a truly happy and relieving moment to find out after five years that we are at least on the same side of the 2 party system here in the US. We had all avoided any political topics studiously for five years.