A new resource from the Gene Ontology Consortium, a comprehensive encyclopedia of the known functions of all protein-coding human genes, has just been completed and released on a new website. For the first time, researchers from the Keck School of Medicine of USC, the Swiss Institute of Bioinformatics and other institutions used large-scale evolutionary modeling to integrate data on human genes with genetic data collected from other organisms. This has culminated in a searchable public resource that lists the known functions of more than 20,000 genes using the most accurate and complete evidence available.